PQQ, full name 4, 5-dihydro-4, 5-dioxy-1-hydropyrrole (2, 3-f) quinolin-2, 7, 9-tricarboxylic acid, also known as pyrroloquinoline quineone (PQQ), is produced by Gram-negative bacteria, and has a wide range of nutritional effects on microorganisms, animals and plants. And have antioxidant nutrients. So what are the functions of Pqq? Why is PQQ
Boosting Immunity Extract?
(1) Protect the heart from oxidative damage and Sleeping Aid Extract
The protective effect of PQQ on the heart is related to its ability to scavenge free radicals. PQQ can clear reactive oxygen species (ROS) generated by hypoxia reperfusion and significantly reduce the release of lactate dehydrogenase in the heart. Under the catalysis of flavin reductase, its catalytic products can also reduce the peroxidation state of hemoglobin and eliminate the myocardial damage caused by hypoxia reperfusion. Studies have shown that the use of PQQ to protect the hearts of ischemia-reperfusion mice significantly reduces the extent of myocardial infarction, enhances left ventricular pressure and left ventricular diastolic pressure rise and fall rate, reduces ventricular fibrillation, and reduces the level of malondialdehyde in myocardial tissue. PQQ can also inhibit the generation of ROS and the reduction of mitochondrial membrane potential induced by hydrogen peroxide in rat cardiomyocytes, thereby reducing oxidative stress, inhibiting the inactivation of mitochondrial function, and protecting rat cardiomyocytes.
(2) Prevention and treatment of liver injury
Improved Digestion Extract Experimental liver injury caused by carbon tetrachloride (CCl), galactosamine, acetamide sulfide and other toxins in rats can be prevented by intraperitoneal injection of PQQ and its derivatives. PQQ can reduce the ROS production induced by hepatotoxic substances, significantly reduce the levels of serum glutamic pyruvic transaminese (GPT) and lactate dehydrogenase, block liver cell necrosis, and do not affect the conventional biochemical indicators (such as blood glucose, blood nitrogen, etc.) of rats.
(3) Promote nerve growth and protect the nervous system
nerve growth factor (NGF) is the first neurotrophic factor discovered and the most thoroughly studied. It has dual biological functions of neuronal nutrition and neuroprotection, and plays an important regulatory role in the growth, development, differentiation, regeneration and specific expression of biological functions of central and peripheral neurons. Experiments show that PQQ can stimulate L-M cells and Schwann cells to produce NGF in vitro.
(4) Prevent acetaldehyde poisoning
Nutritional Supplements Acetaldehyde is the intermediate metabolite of alcohol in animals, which is toxic. Many people have the mutation and insufficiency of acetaldehyde dehydrogenase gene, which leads to acetaldehyde accumulation after drinking, resulting in slight acetaldehyde poisoning reactions such as red face and dizziness.
Experiments with rodents have shown that PQQ helps metabolize acetaldehyde. Before injecting ethanol into the stomach, PQQ was injected into the abdominal cavity (the dose was 11.5mg/kg body weight). The experiment found that the concentration of ethanol in the blood and liver of the treated group was not significantly different from that of the control group, but the concentration of acetaldehyde in the former group was much lower than that in the latter group. Replacing PQQ with other quinone derivatives, such as coenzyme Q10, has a similar effect.
